| Mass spectrometry based on nanomaterials |
|
Jong-Min Park, Joo-Yoon Noh, Moon-Ju Kim, Jae-Chul Pyun |
|
Materials Science and Engineering, Yonsei University |
| 나노물질을 이용한 질량분석 기술 개발동향 |
|
박종민, 노주윤, 김문주, 변재철 |
|
연세대학교 신소재공학과 |
|
|
| Abstract |
|
In conventional MALDI-TOF mass spectrometry, analyte molecules are known to be ionized by mixing with organic matrix molecules. As the organic matrix molecules are made into small fragments, they generate unreproducible mass peaks such that MALDI-TOF mass spectrometry is nearly impossible in the low mass-to-charge (m/z) range (< 1000). Additionally, the dried sample mixed with matrix were made as inhomogeneous crystal on metal plate. When the laser radiation was made on the sample crystal, the amount of generated sample ion was observed to be quite different according to the radiation point. Therefore, the quantitative analysis was very difficult even for the sample spots at the same concentration for the conventional MALDI-TOF mass spectrometry. In this work, we present laser desorption/ionization (LDI) mass spectrometry based on solid-matrices for the quantitative analysis of small molecules in the low m/z range by using MALDI-TOF mass spectrometry: (1) Carbon based nanostructures; (2) Semiconductor based nanomaterials; (3) Metal based nanostructures. |
| Key Words:
LDI-mass spectrometry, MALDI-TOF, solid-matrix, quantitative analysis |
|
PDF Links
Full text via DOI
Download Citation
E-Mail
